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An online GPCR structure analysis platform.

Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark. albert.kooistra@sund.ku.dk. Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark. Data Tools Department, Novozymes A/S, Copenhagen, Denmark. Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark. david.gloriam@sund.ku.dk.

Nature structural & molecular biology. 2021;(11):875-878
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Abstract

We present an online, interactive platform for comparative analysis of all available G-protein coupled receptor (GPCR) structures while correlating to functional data. The comprehensive platform encompasses structure similarity, secondary structure, protein backbone packing and movement, residue-residue contact networks, amino acid properties and prospective design of experimental mutagenesis studies. This lets any researcher tap the potential of sophisticated structural analyses enabling a plethora of basic and applied receptor research studies.